or simply phenyl-2-nitropropene, or P2NP, as it is commonly referred to, is a chemical compound from the
aromatic group of compounds, with the formula C9H9NO2. It is a light-yellow crystalline solid with a distinct
smell. Phenyl-2-nitropropene is used in the pharmaceutical industry to manufacture the drug Adderall,
an amphetamine mixture used to treat ADHD and narcolepsy. P2NP and other similar nitrostyrenes are also
employed in the clandestine manufacture of drugs of the amphetamine class, and are listed as drug precursors
in many countries.
In the pharmaceutical industry, P2NP is used to produce a racemic amphetamine mixture, branded under the
trade names Adderall and Mydayis, amongst others. In this case, the double bond is hydrogenated and the
nitro group is reduced, thus 1-phenyl-2-nitropropene becomes 1-phenyl-2-aminopropane, which is another
name for amphetamine. Different reducing agents and solvents are used for this reaction, and various protocols
exist. Often lithium aluminium hydride (LAH), aluminum amalgam or Raney nickel are used as a reducing agent,
and the reaction is carried in a solvent like isopropyl alcohol or THF
Safety and Storage:
P2NP is labeled as harmful by the GHS, and is a known irritant. Thus, breathing fumes and direct skin and eye
contact should be avoided. The median lethal dose for oral exposure in rats and mice is greater than 500 mg/kg
and 1176 mg/kg, respectively. Based on available data, the classification criteria are not met to classify P2NP as
a carcinogen. However, the toxicological properties have not been thoroughly investigated.
P2NP should be stored at 2°C to 8°C and away from strong oxidizing agents. At higher temperatures, P2NP is not
very stable, and degrades with time.
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